Funded by


Subproject C.1

Modeling of proteins under non-natural conditions:

structure, flexibility, and aggregation

In sub-project C.1, proteins that are widely used in industrial biotechnology are simulated under non-natural conditions to investigate the molecular mechanism of binding of solvent molecules to the protein surface, the unfolding and aggregation of proteins by organic solvents, high pressure or temperature. A more detailed understanding of the changes of protein structure and dynamics is a prerequisite for the design of improved biocatalysts and the optimization of process conditions.

Further information about this subproject